Doctor preparing injection for an allergy shot

How Do Allergy Shots Work?

Allergy shots are a form of immunotherapy, and the idea behind them is simple. They gently expose your body to tiny amounts of what you’re allergic to, so that over time your immune system learns to stop treating it like a threat. It’s the same principle as a vaccine: a small, controlled exposure that helps your body build a lasting response.

Treatment usually happens in two phases:

  • Build-up phase: You’ll come in for shots one to two times a week while your allergist slowly increases the dose. This typically lasts three to six months.
  • Maintenance phase: Once you reach your target dose, visits stretch out to about once a month and continue for three to five years.
  • Many people start noticing fewer, milder symptoms during the build-up phase, and relief tends to keep improving the longer they stay with it. Allergy shots are one type of immunotherapy. 

    Prefer to skip needles? If needles really aren’t your thing, allergy drops (taken under the tongue at home) may be an option worth asking about.

    What To Expect During Allergy Shots

    What to Expect at Your Allergy Shot Appointment

    A standing appointment can sound like a lot, so here’s the honest version of what it looks like.

    Each visit is quick, usually just a few minutes for the shot itself. Afterward, you’ll stay in the office for about 15–30 minutes so your care team can make sure you’re feeling good before you head out.


    That short wait is the most important part of the visit, and it’s exactly why allergy shots are given with us rather than on your own.
    Phase 1

    Build-up phase

    1–2 short visits a week

    For about three to six months, as your allergist gradually builds your dose.

    Phase 2

    Maintenance phase

    Roughly one visit a month

    Continuing for three to five years, once you reach your target dose.

    It’s a commitment, but a manageable one, as most people find a visit fits into a lunch break.


    See what to expect as an AllerVie patient

    How to Prepare for Your Visit

    Check in about your medications

    Some people take an antihistamine before a shot to ease reactions. Ask your allergist what’s right for you, and don’t start or stop any medication without checking first.

    Skip the hard workout beforehand

    Intense exercise right before a shot can move the medication through your body too quickly. Give yourself a couple of hours of downtime before and after.

    Speak up if you’re feeling off

    Let your care team know if you’re sick, run-down, or having asthma symptoms before a shot. It helps them keep every visit safe.

    01

    Check in about your medications

    Some people take an antihistamine before a shot to ease reactions. Ask your allergist what’s right for you, and don’t start or stop any medication without checking first.

    02

    Skip the hard workout beforehand

    Intense exercise right before a shot can move the medication through your body too quickly. Give yourself a couple of hours of downtime before and after.

    03

    Speak up if you’re feeling off

    Let your care team know if you’re sick, run-down, or having asthma symptoms before a shot. It helps them keep every visit safe.

    Ready to Start Allergy Shot Treatment?

    Allergy shots may help reduce symptoms over time by addressing your specific allergy triggers. Schedule an appointment to find out if immunotherapy is right for you.

    Side effects of allergy shots

    As with any medical intervention, allergy immunotherapy can involve some side effects, which can include:

    Local Reactions (Most Common)

    Patients may develop redness, irritation or swelling at the site of the shot. These local reactions are common and do not typically last longer than a few hours.

    Systemic Reactions (Least Common)

    Systemic reactions manifest through sneezing, congestion or even hives. In severe cases, patients may experience swelling in the throat and wheezing.

    Anaphylaxis (Extremely Rare)

    A patient may go into anaphylactic shock after an allergy shot. This is a life-threatening condition that involves low blood pressure and difficulty breathing.

    *Anyone experiencing symptoms of anaphylaxis should seek out medical care immediately.

    How To Know It’s Time To Try Allergy Shots

    Allergy shots are not right for every patient. Any patient considering allergy shots should consult with their doctor or allergist to discuss their options. How can you know if allergy shots are right for you? Patients are a good fit for allergy shots if they:

    • Have a condition that can be treated with allergy shots
    • Wish to reduce long-term use of allergy medications
    • Have no fear of needles
    • Have no control over exposure to an allergen (i.e. insect sting allergy)
    • Have had little success with controlling symptoms via medications

    Frequently Asked Questions

    How Long Does It Take for Allergy Shots To Work?

    How Effective Are Allergy Shots?

    Do Allergy Shots Lower Your Immune System?